منابع مشابه
Changes in Subcellular Distribution of n-Octanoyl or n-Decanoyl Ghrelin in Ghrelin-Producing Cells
BACKGROUND The enzyme ghrelin O-acyltransferase (GOAT) catalyzes the acylation of ghrelin. The molecular form of GOAT, together with its reaction in vitro, has been reported previously. However, the subcellular processes governing the acylation of ghrelin remain to be elucidated. METHODS Double immunoelectron microscopy was used to examine changes in the relative proportions of secretory gran...
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Ghrelin exerts various metabolic activities, including regulation of glucose levels in humans. To verify whether the glucose response to ghrelin reflects a modulation of an insulin-independent hepatic phenomenon, we studied glucose output by primary porcine hepatocytes in suspension culture, after incubation with acylated ghrelin (AG), unacylated ghrelin (UAG), and hexarelin (HEX). AG induced g...
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lin Measurements: Octanoyl Modification of Ghrelin Is Rapidly Hydrolyzed to Desacyl Ghrelin in Blood Samples, Hiroshi Hosoda, Kentaro Doi, Noritoshi Nagaya, Hiroyuki Okumura, Eiichiro Nakagawa, Mitsunobu Enomoto, Fumiaki Ono, and Kenji Kangawa ( Department of Biochemistry, National Cardiovascular Center Research Institute, and 2 Department of Internal Medicine, National Cardiovascular Center, O...
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Real-time measurements for gut motility in conscious rats or mice combined with intracerebroventricular or intravenous injection of peptide agonists or antagonists allow us to understand the regulatory mechanism of gastrointestinal motility. Neuropeptide Y (NPY) in the arcuate nucleus in the hypothalamus stimulates the fasted motility in the duodenum, while urocortin in the paraventricular nucl...
متن کاملRapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.
To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2005
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2005-0353